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High Purity Benfotiamine Powder

High Purity Benfotiamine Powder

Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect.

Details

【Product Name】High Purity Benfotiamine powder

【CAS No.】22457-89-2

【Molecular Formula】C19H23N4O6PS

【Molecular Weight】466.45

【Appearance】White powder

 ISO Certificate Benfotiamine powder

Description Of Benfotiamine

Benfotiamine (rINN, or S-benzoylthiamine Omonophosphate) is a synthetic Sacyl derivative of thiamine (vitamin B1). It has been licensed for use in Germany since 1993. It is prescribed there for treating sciatica and other painful nerve conditions.  

Benfotiamine is marketed as a dietary supplement and is not a medicine.  Benfotiamine is primarily marketed as an antioxidant dietary supplement. In a clinical study with six patients, benfotiamine lowered

AGE by 40%.

Benfotiamine may be useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy. 

However, most of the effects attributed to benfotiamine are extrapolated from in vitro and animal 

studies. Unfortunately, apparent evidences from human studies are scarce and especially endpoint 

studies are missing. Therefore, additional clinical studies are mandatory to explore the therapeutic 

potential of benfotiamine in both diabetic and non-diabetic pathological conditions.  It is thought 

that treatment with Benfotiamine leads to increased intracellular thiamine  diphosphate levels, a 

cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, 

ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.


Test  Item

Analysis  Specification

Result

Description

White to almost white crystal

White to almost white crystal

Identification

A: IR spectra shows the similarity between sample and standard

B: The retention time of the major peak corresponds with it of the reference standard

Complies

Complies

Solution color and clearness

Colorless to pale-yellow clear solution

Complies

Chlorides

Not more than 0.053%

<0.053%

Sulphate

Not more than 0.011%

<0.011%

Loss on drying

Not more than 1.5%

0.66%

Heavy metals

Not more than 0.002%

<0.002%

Related Substances

TMP :Not more than 0.15%

Benzoic acid :not more than0.1%

Amide: not more than 0.40%

Single unknown impurity: not more than0.1%

Thiamine: not more than0.1%

Total impurities: Not more than 1.5%

<0.025%

No detectable

0.06%

0.08%

No detectable

0.33%

Residual solvents

Dichloromethane: not more than 600ppm

Isopropanol: not more than300ppm

No detectable

64ppm

Microbial limits

Total bacteria: not more than100cfu/g

Yeast and mould: not more than50cfu/g

Escherichia coli: no detectable

<10 cfu/g

<10 cfu/g

No detectable

Assay(Dry Basis)

98.0%~102.0%

99.6%

Conclusion: Complies with company Standard.


 Function & Application

1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency; 

2.  It is used in the treatment of non alcoholic wernicke encephalopathy;

3. To treat beriberi; 

4.  For vitamin B1 demand increase, with inadequate intake from foods supplies (fatigue, hyperthyroidism, pregnancy, lactation, during strenuous manual labor, etc.

 

Storage&Packaging

【Storage】Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.

【Packaging】25kg/Drum.

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