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Benfotiamine

Benfotiamine

Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect.

Details

【Product Name】Benfotiamine

【CAS No.】22457-89-2

【Molecular Formula】C19H23N4O6PS

【Molecular Weight】466.45

【Appearance】White powder

 ISO Certificate Benfotiamine powder

Description Of Benfotiamine

Benfotiamine is vitamin B1 fat soluble derivatives, improve the bioavailability of water-soluble vitamin B1 low shortcomings, improve the blood and tissue concentrations of thiamine, so as to improve the curative effect.


Benfotiamine may be useful for the treatment of diabetic retinopathy, neuropathy, and nephropathy. However, most of the effects attributed to benfotiamine are extrapolated from in vitro and animal studies. Unfortunately, apparent evidences from human studies are scarce and especially endpoint studies are missing. Therefore, additional clinical studies are mandatory to explore the therapeutic potential of benfotiamine in both diabetic and non-diabetic pathological conditions.  It is thought that treatment with Benfotiamine leads to increased intracellular thiamine  diphosphate levels, a cofactor of transketolase. This enzyme directs advanced glycation and lipoxidation end products (AGE's, ALE's) substrates to the pentose phosphate pathway, thus reducing tissue AGEs.


Test  Item

Analysis  Specification

Result

Description

White to almost white crystal

White to almost white crystal

Identification

A: IR spectra shows the similarity between sample and standard

B: The retention time of the major peak corresponds with it of the reference standard

Complies

Complies

Solution color and clearness

Colorless to pale-yellow clear solution

Complies

Chlorides

Not more than 0.053%

<0.053%

Sulphate

Not more than 0.011%

<0.011%

Loss on drying

Not more than 1.5%

0.66%

Heavy metals

Not more than 0.002%

<0.002%

Related Substances

TMP :Not more than 0.15%

Benzoic acid :not more than0.1%

Amide: not more than 0.40%

Single unknown impurity: not more than0.1%

Thiamine: not more than0.1%

Total impurities: Not more than 1.5%

<0.025%

No detectable

0.06%

0.08%

No detectable

0.33%

Residual solvents

Dichloromethane: not more than 600ppm

Isopropanol: not more than300ppm

No detectable

64ppm

Microbial limits

Total bacteria: not more than100cfu/g

Yeast and mould: not more than50cfu/g

Escherichia coli: no detectable

<10 cfu/g

<10 cfu/g

No detectable

Assay(Dry Basis)

98.0%~102.0%

99.6%

Conclusion: Complies with company Standard.


Function & Application Of Benfotiamine


1. Benfotiamine is used for the prevention and treatment of vitamin B1 deficiency;

2..Benfotiamine is used in the treatment of non alcoholic wernicke encephalopathy;

3. Benfotiamine is used in the following diseases, speculation and vitamin B1 deficiency and metabolic disorders associated with treatment, such as: neuralgia; Muscle pain, joint pain; Peripheral neuritis, peripheral nerve palsy; Myocardial metabolic disorders; Constipation and other gastrointestinal motor function obstacle.

 

Storage&Packaging

【Storage】Store in tight, light-resistant containers, avoid exposure to direct sunlight, moisture and excessive heat.

【Packaging】25kg/Drum.

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